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目的 探讨骨髓增生异常综合征 (MDS)合并自身免疫性疾病的特点。方法 对 1997- 0 1～ 2 0 0 2 -0 6中山大学附属第二医院消化科 6 0例MDS患者的临床资料进行分析和随访观察。结果 6 0例MDS患者中 ,5例合并自身免疫性疾病 ,其中格雷夫斯病 3例 ;合并自身免疫性疾病患者MDS的分型以环形铁粒幼细胞性难治性贫血 (RAS)最多见 (4例 )。结论 MDS可以合并格雷夫斯病 ,而体液免疫异常可能是MDS合并自身免疫性疾病的一个重要环节。FAB分型与是否合并自身免疫性疾病之间可能并无相关。
Objective To investigate the characteristics of myelodysplastic syndrome (MDS) combined with autoimmune diseases. Methods The clinical data of 60 patients with MDS from Department of Gastroenterology, Second Affiliated Hospital of Sun Yat-sen University from 1997 to 2001-02 were analyzed and followed up. Results Among the 60 patients with MDS, 5 had autoimmune diseases, of which 3 were Graves’ disease. The type of MDS in patients with autoimmune diseases was most commonly seen with ring-like granulocyte-refractory anemia (RAS) (4 cases). Conclusion MDS can be combined with Graves’ disease, and abnormal humoral immunity may be an important part of MDS combined with autoimmune diseases. There may not be any correlation between FAB typing and whether or not autoimmune diseases are combined.