本文报道~3H-氧甲基山豆根碱的药物代谢动力学。大白鼠一次灌胃给药后,血浆药物浓度对时问的曲线符合开放式二室模型。其主要参数是:t1/2_(Ka)=0.203hr t1/2_a=0.481hr,t1/2_β=9.429hr, K_(12)=0.582hr~(-1), K_(21)=0.799hr~(-1), K_(10)=0.132hr~(-1), T_(max)=0.61hr, C_(max)=0.461μg/m1。收集48小时内大白鼠的粪、尿测得排出的放射性分别为21.59%和1.97% This paper reports the pharmacokinetics of ~ 3H-oxymethyl caeruleine. After intragastric administration to rats, the curve of plasma drug concentration to time was in accordance with the open two-compartment model. The main parameters are: t1 / 2_ (Ka) = 0.203hr t1 / 2_a = 0.481hr, t1 / 2_β = 9.429hr, K_ (12) = 0.582hr_1, K_ (21) = 0.799hr ~ -1), K 10 = 0.132 hr -1, T max = 0.61 hr and C max = 0.461 μg / m 1. Collected within 48 hours of rat fecal urine was measured emissions of radioactivity were 21.59% and 1.97%