本文用~3H-DL-四氢巴马汀作示踪剂,研究了四氢巴马汀在大鼠体内的分布和排泄。实验结果表明,静注给药后,药物广泛分布于肾、肝、肺、心和脑组织中。而且脑组织内的放射性活性高于血液,证明此药可以透过血脑屏障。药物通过尿和粪便排泄,给药后136h,经尿排出的放射性活性为给药量的70%,而从粪便中排出的放射性活性则为15%。 In this paper, ~ 3H-DL-tetrahydropalmatine was used as a tracer to study the distribution and excretion of tetrahydropalmatine in rats. The experimental results show that, after intravenous administration, the drugs are widely distributed in the kidney, liver, lung, heart and brain tissue. And radioactivity in brain tissue is higher than that of blood, proving that the drug can cross the blood-brain barrier. Drugs were excreted through urine and feces, and radioactivity was excreted by urine at 136 hours after administration, accounting for 70% of the administered dose and 15% of excreted radioactivity.