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目的观察甲地孕酮在晚期肿瘤含铂类药物化疗中对患者的生活质量影响。方法256例晚期肿瘤患者随机分为化疗+甲地孕酮组及单纯化疗组。结果食欲改善,食量增加治疗组72.8%,对照组12.5%,P<0.01。Ⅲ～Ⅳ度恶心、呕吐治疗组5.8%,对照组24.2%,P<0.01。Ⅲ～Ⅳ度骨髓抑制治疗组16.2%,对照组25%,P<0.05。KPS改善>10%治疗组73.5%,对照组10.8%,P<0.01。结论甲地孕酮在晚期肿瘤含铂类药物化疗中有食欲改善,食量增加,减少胃肠道反应。保护骨髓,从而改善患者的生活质量。
Objective To observe the influence of megestrol on the quality of life of patients with chemotherapy of advanced platinum-containing drugs. Methods 256 patients with advanced cancer were randomly divided into chemotherapy plus megestrol and chemotherapy alone group. Results appetite improved, food intake increased 72.8% in treatment group, 12.5% in control group, P <0.01. Ⅲ ~ Ⅳ degree nausea, vomiting treatment group 5.8%, control group 24.2%, P <0.01. 16.2% in the group of Ⅲ ~ Ⅳ myelosuppression and 25% in the control group, P <0.05. KPS improvement> 10% in the treatment group 73.5%, the control group 10.8%, P <0.01. Conclusion Megestrol in patients with advanced cancer platinum-containing chemotherapy has improved appetite, food intake, reduce gastrointestinal reactions. Protect the bone marrow, thereby improving the quality of life of patients.