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肿瘤起源于干细胞的假说已在人类许多实体瘤中得到证实,近来亦发现肝癌中存在肝癌干细胞。肿瘤干细胞被认为是肿瘤产生的根源,对肿瘤的发生、发展、转移、复发及耐药具有关键作用。因此,如何分离鉴定肝癌干细胞对于改善预防方法、促进早期检测以及研发新的治疗方法都是一个非常紧迫的课题。本文就肝癌干细胞的来源、表面标志、分选方法、应用前景及存在的问题作一综述。
The hypothesis that tumors originate from stem cells has been confirmed in many solid tumors in humans and more recently liver cancer stem cells have also been found in liver cancer. Cancer stem cells are considered to be the source of tumors and play a key role in tumorigenesis, development, metastasis, recurrence and drug resistance. Therefore, how to separate and identify HCC stem cells is a very urgent issue for improving the prevention methods, promoting early detection and developing new treatment methods. This article reviews the sources, surface markers, sorting methods, application prospects and existing problems of HCC stem cells.