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非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)以其迅速增长的发病率成为日益严重的全球性健康问题。近年来,越来越多的证据表明,肠道菌群(intestinal microbiota,IM)在NAFLD的发病机制中起到重要作用。IM与NAFLD的危险因素,如肥胖、胰岛素抵抗及糖尿病等密切相关,并且通过参与能量物质及胆汁酸代谢,增加内源性酒精的产生,提高肠黏膜屏障通透性、促进肝脏炎症及纤维化等过程,推动NAFLD的发生发展。文章对IM在NAFLD的作用机制进行阐述,以期为NAFLD的治疗提供新思路。
Non-alcoholic fatty liver disease (NAFLD) is an increasingly serious global health problem with its rapidly growing incidence. In recent years, more and more evidences indicate that intestinal microbiota (IM) plays an important role in the pathogenesis of NAFLD. IM and NAFLD risk factors such as obesity, insulin resistance and diabetes are closely related, and through the participation of energy substances and bile acid metabolism, increased endogenous alcohol production, improve intestinal mucosal barrier permeability, promote liver inflammation and fibrosis And other processes to promote the occurrence and development of NAFLD. This article describes the mechanism of IM in NAFLD, in order to provide new ideas for the treatment of NAFLD.