目前为止临床应用的肿瘤光化学诊治剂均系由血液或血红素及血卟啉制得,成品组成比较复杂。1984年国外报道了脱镁叶绿酸α对体外培养人癌细胞的光灭活作用,但未见有关结构分析和理化参数以及肿瘤光生物活性的进一步报道。我们首次从蚕沙糊状叶绿素分离制备得脱镁叶绿酸化合物,并初步测 Until now, the clinically used tumor photochemical diagnosis and treatment agents have been obtained from blood or heme and hematoporphyrin, and the finished product composition is relatively complex. In 1984, the photoinactivation effect of pheophorbide alpha on cultured human cancer cells was reported abroad, but no further reports on structural analysis and physicochemical parameters and on the photobioactivity of tumors were found. For the first time, we isolated the pheophorbide compounds from the silkworm pupa chlorophyll and measured