论文部分内容阅读
目的：研究疾宁康醇提物对阿霉素（ＡＤＲ）所致心肌细胞损伤的影响。方法：采用体外心肌细胞培养，观察疾宁康醇提物对心肌细胞博动频率及对心肌细胞培养液中ＬＤＨ活力和ＭＤＡ含量的影响。结果：疾宁康４８００和４８０μｇ／ｍｌ均能明显对抗ＡＤＲ所致受损心肌细胞ＭＤＡ含量和ＬＤＨ活力的升高。４８μｇ／ｍｌ仅能使心肌细胞ＭＤＡ含量下降，对ＬＤＨ活力未见明显影响。疾宁康还能使受损心肌细胞博动频率加快。结论：疾宁康对ＡＤＲ所致心肌细胞损伤有保护作用。
Objective: To study the effects of Ji Ning Tan alcohol extract on doxorubicin (ADR) induced cardiomyocyte injury. Methods: In vitro cardiomyocyte culture was used to observe the effects of JXN on cardiomyocyte motility and LDH activity and MDA content in cardiomyocyte culture medium. Results: Jiuningkang 4800 and 480μg / ml could obviously antagonize the increase of MDA content and LDH activity of damaged myocardial cells induced by ADR. 48μg / ml can only make the myocardial MDA content decreased, no significant effect on LDH activity. Ning Ning Kang can make impaired cardiomyocytes frequency of exercise faster. Conclusion: Ji Ning Kang protective effect of ADR induced cardiomyocyte injury.