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已知,在枸椽酸克罗米芬(CC)诱发的排卵周期中妊娠率较低,主要原因之一是CC治疗后黄体期缺陷(LPD)的发病率高。作者在以前的工作中发现,用CC与hCG促排卵后,在血浆孕酮浓度显著高于正常生育对照组的不育患者中,42.3%分泌相有缺陷。关于LPD的治疗,作者以前曾提出:(1)排卵后给去氢孕酮不会抑制血浆孕酮(P)水平;(2)去氢孕酮能使68.7%的异常子宫内膜分泌期得以纠正。本工作目的:研究去氢孕酮补充疗法对于CC-hCG治疗后子宫内膜LPD的治疗效果。 20例无排卵和月经过少的不育患者,在第一个CC-hCG促排卵的周期中,血浆E_2与P虽正常,但
It is known that one of the primary causes of lower pregnancy rates during clomiphene citrate-induced ovulation cycles is the high incidence of luteal phase defects (LPD) after CC treatment. In previous work, the authors found that 42.3% of the secretory phase was deficient in infertile patients whose plasma progesterone concentrations were significantly higher than that of the normal fertility control group after ovulation with CC and hCG. With regard to the treatment of LPD, the authors have previously proposed: (1) dehydrogenation of progesterone after ovulation does not inhibit plasma progesterone (P) levels; (2) dehydrogenation progesterone can make 68.7% of abnormal endometrial secretions can be correct. The purpose of this study: To study the effect of dehydrogesterone replacement therapy on endometrial LPD after CC-hCG treatment. 20 cases of anovulatory and menorrhagia patients with infertility, in the first cycle of ovulation induction of CC-hCG, plasma E_2 and P, although normal, but