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目的探讨生物学因素在急性淋巴细胞白血病(ALL)中的预后价值;研究白细胞介素-6(IL-6)基因启动子区域-174G/C基因多态性与中国西北汉族人ALL的相关性。方法收集临床资料,分析患者生物学因素包括性别、年龄、外周血白细胞计数、骨髓原始细胞数、Ph染色体、并发症进行危险度分层,诱导治疗第一疗程结束得到完全缓解(CR1)作为疗效评估;各生物学特征比较采用χ2检验;IL-6基因-174G/C多态性用RFLP方法检测。结果患者性别、初诊时是否伴有Ph染色体异常,是否伴有并发症对第一疗程的缓解率无显著影响(P值>0.05);初诊时患者的年龄>30岁,外周血白细胞数>50×109/L与第一疗程的疗效密切相关(P值<0.05);ALL组与对照组IL-6基因-174G/C位点的等位基因频率及基因型频率与对照组组相同。结论患者的年龄、初诊时白细胞数对评估ALL患者的预后有显著意义;IL-6基因-174G/G基因多态性与ALL的发病可能无相关性,其中G等位基因可能不是我国西北汉族人ALL发病的遗传易感性基因。
Objective To investigate the prognostic value of biological factors in acute lymphoblastic leukemia (ALL) and to investigate the association between -174G / C polymorphism in the IL-6 promoter region and ALL in Chinese Han population of Northwest China . Methods The clinical data were collected and analyzed for biological factors including gender, age, peripheral blood leukocyte count, number of bone marrow blasts, Ph chromosome, risk stratification of complications, and complete response (CR1) at the end of the first course of induction therapy The biological characteristics were compared by χ2 test. The IL-6 gene-174G / C polymorphism was detected by RFLP. Results Patient’s gender, Ph chromosome abnormalities at the time of first visit, whether accompanied by complications of the first course of remission rate had no significant effect (P value> 0.05); first visit patients age> 30 years, peripheral blood leukocytes> 50 × 109 / L was closely related to the efficacy of the first course of treatment (P <0.05). The allele frequency and genotype frequency of IL-6 gene -174G / C locus in ALL and control groups were the same as those in control group. Conclusions The age of the patients and the number of white blood cells in newly diagnosed cases are significant for evaluating the prognosis of patients with ALL. The IL-6 gene-174G / G polymorphism may not be associated with the pathogenesis of ALL. The G allele may not be the Han Chinese Genetic susceptibility genes in human ALL.