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目的观察含有呋喃唑酮的四联疗法与标准三联疗法根除幽门螺杆菌(Hp)的疗效差异,寻找根除Hp的最佳治疗方案。方法 150例Hp患者,随机分为治疗组和对照组,每组75例。治疗组采用四联方案:兰索拉唑肠溶片20 mg/次,呋喃唑酮片100 mg/次,阿莫西林胶囊1000 mg/次,胶体果胶铋胶囊200 mg/次,早晚各1次,疗程14 d;对照组采用标准三联治疗方案:兰索拉唑肠溶片20 mg/次,克拉霉素胶囊500 mg/次,阿莫西林胶囊1000 mg/次,早晚各1次,疗程14 d;两组于根除疗程结束1个月后复查~(14)C-尿素呼气试验(~(14)C-UBT)并比较两组的根除效果。结果 150例患者中实际完成144例;治疗组65例Hp根除成功;对照组55例Hp根除成功。治疗组Hp根除成功率(90.3%)高于对照组(76.4%)(P<0.05)。结论含有呋喃唑酮的四联方案根除Hp感染的根除率高,值得临床推广应用。
Objective To observe the curative effect of the combination of furazolidone-containing quadruple therapy with standard triple therapy for the treatment of Helicobacter pylori (Hp) and to find out the best treatment for Hp eradication. Methods 150 cases of Hp patients were randomly divided into treatment group and control group, 75 cases in each group. Treatment group with quadruple program: lansoprazole enteric-coated tablets 20 mg / time, furazolidone tablets 100 mg / time, amoxicillin capsules 1000 mg / time, colloidal pectin bismuth capsules 200 mg / time, morning and evening 1, The course of treatment was 14 days. The control group received the standard triple therapy regimen: lansoprazole enteric-coated tablet 20 mg / time, clarithromycin 500 mg / time, amoxicillin 1000 mg / time, morning and evening 1, ; Two groups after the end of eradication treatment review ~ (14) C-urea breath test (~ (14) C-UBT) and compared the eradication effect of the two groups. Results Of 150 patients, 144 cases were actually completed; 65 cases of Hp eradication were successfully treated in the treatment group; 55 cases of Hp eradication in the control group were successful. The success rate of Hp eradication in the treatment group (90.3%) was higher than that in the control group (76.4%) (P <0.05). Conclusion The four-regimen containing furazolidone has a high eradication rate of H. pylori infection and deserves clinical application.