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我们于1987年2月～1988年12月采用荧光偏振免疫分折法(TDX)测定癫痫患儿苯巴比妥血浓度98例,有效血浓度按15～40ug/ml为标准。低于15ug/ml共35例,现把临床及随访资料较完整的12例分析如下. 病例摘要患儿,男6例,女6例。测血浓度时年龄18月～11岁,其中7～11岁5例,18月～4岁7例。临床表现为反复局限或全身抽搐。经内科和神经系统检查均无阳性发现。智力发育正常。发作同期脑电图检查示:6例有局限性癫痫波发放,其中颞区2例,额枕、额/颞+枕各1例;6例未见癫痫波.其中2例有阵发性Q活动;4例示中一高度异常.在我院神经科门诊拟诊全身性或局限性发作。选用单一苯巴比妥治疗.每日量分2次口服,临床发作控制均在半年以上,作血浓度测定.12例苯巴比妥剂量与血浓度的关系见附表。
We measured 98 cases of phenobarbital in children with epilepsy by fluorescent polarization immune assay (TDX) from February 1987 to December 1988. The effective blood concentration was 15 ~ 40 ug / ml. Less than 15ug / ml a total of 35 cases, the clinical and follow-up data are more complete analysis of 12 cases are as follows.Patients with children, 6 males and 6 females. Blood concentration measured at the age of 18 months to 11 years, of which 7 to 11 years in 5 cases, 18 months to 4 years in 7 cases. Clinical manifestations of repeated limitations or generalized convulsions. Neither medical nor neurological examination found positive. Normal mental development. Seizure EEG examination showed: There were 6 cases of limitations of epilepsy wave release, of which 2 cases of temporal area, frontal, frontal / temporal + pillow in 1 case; 6 cases did not see epileptic waves .2 cases of paroxysmal Q Activity; 4 cases showed a high degree of anomalies in our hospital neurology outpatient diagnosis of systemic or localized attack. Use single phenobarbital treatment daily oral dose of 2 times, clinical seizure control are more than six months for blood concentration determination .12 phenobarbital dose and blood concentration in the relationship table.