TLR-2（Toll-like receptor 2,TLR-2）是哺乳动物TLRs（Toll-like receptors,TLRs）家族的一员,作为细胞表面的天然受体蛋白,主要参与病原微生物产物的识别及炎症信号传导,介导天然抗感染兔疫;最近又发现其参与机体对非感染因子所致炎性组织损伤的识别。通过对TLR-2参与的识别和细胞内信号传导机制的研究,可为深入探讨抵御微生物感染的机制、对自身正常与非正常组织的识别提供新的思路。 Toll-like receptor 2 (TLR-2) is a member of the mammalian TLRs family. As a natural receptor protein on the cell surface, TLR-2 is mainly involved in the identification of pathogenic microorganisms and inflammatory signals Conduction, mediate natural anti-infectives; recently found its involvement in the body to identify non-infectious factor-induced inflammatory tissue damage. Through the study of recognition of TLR-2 and the mechanism of intracellular signal transduction, we can provide new ideas for further exploring the mechanism of resisting microbial infection and identifying the normal and abnormal tissues.