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糖尿病是由多种致病因素共同作用于机体引起的以慢性高血糖为主要临床特点的全身慢性代谢性疾病,可以累及多个系统和多个脏器。鉴于糖尿病研究的复杂性,越来越多的科学家使用蛋白质组学方法和技术研究糖尿病及其包括糖尿病肾病和糖尿病视网膜病变在内的慢性并发症。目前糖尿病的蛋白质组学研究多集中于比较糖尿病个体与正常个体组织、血清等样品,筛查和鉴定其中差异表达的蛋白,处于对疾病研究初期的摸索阶段。随着蛋白质组学技术的不断完善、数据的累积和研究的系统化,未来发展的重点将集中于针对部分重要蛋白进行系统的功能研究,发现其在糖尿病及其慢性并发症发病过程中所扮演的角色,为了解糖尿病及其慢性并发症的发病机制、阐明环境因素与疾病发生发展的关系、鉴定疾病的分子标志、寻找新的药物靶点提供新的途径。
Diabetes is caused by a variety of pathogenic factors in the body caused by chronic hyperglycemia as the main clinical features of chronic metabolic diseases, can affect multiple systems and multiple organs. Due to the complexity of diabetes research, more and more scientists use proteomics methods and techniques to study diabetes and its chronic complications including diabetic nephropathy and diabetic retinopathy. At present, the proteomics research of diabetes mostly focuses on the comparison of diabetic individuals and normal individual tissues and serums, screening and identifying the differentially expressed proteins, which is in the early stage of disease research. With the improvement of proteomics technology, the accumulation of data and the systematization of research, the future development will focus on the systematic study of some important proteins and find that they play a role in the pathogenesis of diabetes and its chronic complications To understand the pathogenesis of diabetes mellitus and its chronic complications, clarify the relationship between environmental factors and the development of the disease, identify the molecular markers of the disease and find new drug targets.