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目的 探讨增龄与血清总三碘甲腺原氨酸 (TT3 )、总甲状腺素 (TT4)、甲状旁腺素全段 (PTH- SP)、降钙素 (CT)、睾酮 (T)、雌二醇(E2 )、骨钙素 (BGP)、尿脱氧吡啶啉 /尿肌酐 (DPD/ Cr)及骨密度 (BMD)的关系。方法 2 2 6例健康中老年人分中年组、老年前组、老年组测定血清上述钙调节相关激素、骨转换指标 ,双能 X光骨密度仪测定腰椎、髋部、前臂八个区域的 BMD值 ,比较三组间差异及与年龄的相关性。结果 T(男性 )、E2 (女性 )、TT4、CT、BGP随增龄逐渐下降并与年龄呈显著负相关 (P<0 .0 0 1 ,P<0 .0 5) ,PTH- SP、DPD/ Cr逐渐升高并与年龄显著正相关 (P<0 .0 5)。各部位 BMD值随增龄逐渐降低 ,三组间有显著性差异 (P<0 .0 0 1 )。结论 血清钙调节相关激素浓度随增龄发生变化 ,这些改变引起骨吸收增加 ,骨形成减少 ,骨代谢向负平衡发展 ,可能是原发性骨质疏松的主要因素。
Objective To investigate the relationship between aging and serum total triiodothyronine (TT3), total thyroxine (TT4), total parathyroid hormone (PTH-SP), calcitonin (CT), testosterone (E2), BGP, DPD / Cr and BMD were measured. Methods Twenty-six healthy middle-aged and elderly people were divided into the middle-aged group, the aged group and the elderly group. Serum levels of the above-mentioned hormones and bone turnover-related hormones were measured. Dual energy X-ray absorptiometry BMD value, comparing the differences between the three groups and age-related. Results T (male), E2 (female), TT4, CT, BGP decreased gradually with age and had significant negative correlation with age (P0.01, P0.05), PTH- / Cr increased gradually and positively correlated with age (P <0.05). The BMD of each part gradually decreased with age, with significant difference among the three groups (P <0.01). Conclusion Serum calcium-related hormone concentrations change with age, these changes lead to increased bone resorption, reduced bone formation, bone metabolism to negative balance development may be the primary factor of primary osteoporosis.