多囊肾被认为是一种常见的人类遗传性疾病 ,但近年来许多研究表明该病可能为一种在易感人群中发生的感染性疾病 ,通过 L AL试验可在多囊肾患者的囊液中找到细菌内毒素和真菌 (1→ 3)β- D葡聚糖。囊液中的脂肪酸分析确定了内毒素特征性的 3- OH脂肪酸的存在。血清学试验揭示患者囊液中有孢子菌属抗原 ,抗镰刀菌属及念珠菌 Ig E抗体。对 PKD而言 ,感染性疾病 ,微生物成分和微神经鞘与神经鞘脂生物学之间存在广泛联系 Polycystic kidney disease is considered to be a common human genetic disease, but in recent years, many studies have shown that the disease may be an infectious disease in susceptible populations by L AL test in patients with polycystic kidney disease capsule Bacterial endotoxins and fungi (1 → 3) β-D-glucan were found in the fluid. Fatty acid analysis of the cyst fluid identified the presence of 3-OH fatty acids characteristic of endotoxins. Serological tests revealed that patients with cyst fluid spore antigen, Fusarium and Candida Ig E antibody. For PKD, there is a broad link between infectious diseases, microbial constituents and the biology of microglial sheaths and sphingolipids