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目的观察沙利度胺联合FOLFIRI方案治疗晚期胃癌的临床疗效和毒副反应。方法沙利度胺200 mg,睡前顿服,1～10 d;伊立替康150 mg/m2,静脉滴注90 min,第1天;甲酰四氢叶酸(CF)200 mg/m2,静脉滴注2 h,第1、2天,;5-氟尿嘧啶(5-FU),400 mg/m2,静脉推注,第1、2天,;5-FU 600mg/m2静脉滴注22 h,第1、2天。每2周重复,4周期后评定疗效。结果全组43例患者均可评价疗效,其中CR 4例(9.30%),PR 21例(48.84%),SD 13例(30.23%),PD 5例(11.63%),总有效率RR(CR+PR)58.14%,1年生存率71.88%。主要毒副作用为腹泻(9.38%)、白细胞降低(46.88%)、恶心呕吐(28.13%)。结论该方案治疗晚期结直肠癌有效率高,明显减轻了毒副作用。
Objective To observe the clinical efficacy and side effects of thalidomide combined with FOLFIRI regimen in the treatment of advanced gastric cancer. Methods Thalidomide 200 mg, Dayton clothing, 1 ~ 10 d; irinotecan 150 mg / m2, intravenous infusion 90 min on the first day; leucovorin (CF) 200 mg / m2, intravenous Infusion of 5-fluorouracil (5-FU), 400 mg / m2, intravenous injection, on the first and second days; intravenous infusion of 5-FU 600mg / m2 22 h, 1,2 days. Repeat every 2 weeks, 4 weeks after the assessment of efficacy. Results There were 43 patients (9.30%) in CR, 21 (48.84%) in CR, 13 (30.23%) in SD, and 11.63% in PD + PR) 58.14%, 1-year survival rate of 71.88%. The main side effects were diarrhea (9.38%), leukopenia (46.88%) and nausea and vomiting (28.13%). Conclusion The treatment of advanced colorectal cancer with high efficiency, significantly reduce the toxic side effects.