目的　研究不同种属动物及人血液对梭曼的解毒能力与血液中几种梭曼解毒酶活性的关系。方法　测定血液中梭曼残留浓度及解毒酶活性。结果　小鼠、豚鼠、犬、人血浆对梭曼的解毒能力要明显高于其自身红细胞的解毒能力 ,血浆对梭曼的解毒能力依小鼠、豚鼠、犬、人的顺序由高到低依次排列。啮齿类动物血液中羧酸酯酶 (CaE)活性位点数目多且与梭曼结合快 ,因此在梭曼解毒中可发挥重要作用。犬、人血液中乙酰胆碱酯酶 (AChE)在梭曼解毒中占据了重要的解毒地位 ,犬、人血液中CaE基本没有参与梭曼解毒。结论　血液解毒能力的种属差异与种属间解毒酶结合位点数量的多少及梭曼与酶的结合速率密切相关 Objective To study the relationship between the detoxification ability of Soman and the activity of several soman detoxification enzymes in blood by different species of animal and human blood. Methods Determination of blood residual Soman concentration and detoxification enzyme activity. Results The detoxification ability of mouse, guinea pig, dog and human plasma to soman was significantly higher than that of its own red blood cells. The detoxification ability of plasma to soman was decreased from high to low in order of mouse, guinea pig, dog and human arrangement. Rodents have a large number of carboxylesterase (CaE) active sites in the blood that bind to soman and therefore play an important role in soman detoxification. Canine, human blood acetylcholinesterase (AChE) in Soman detoxification occupies an important detoxification status, dogs, human blood CaE basically did not participate in soman detoxification. Conclusion The difference in species detoxification ability of blood is closely related to the number of detoxification enzyme binding sites in species and the binding rate of soman to enzyme