双氯灭病为新型非自体消炎镇痛解热药，特点是药效强，剂量小，耐受性好。临床主要用于消炎、镇痛及抗风湿等［’1。但该药口服易产生胃肠道不良反应（’），故笔者应用ffi的原理，制备为双氯灭痛擦剂透皮制剂，避免了肝脏首过作用及胃肠道不良反应，透皮吸收效果显著［’）。本文 Diclofenac is a new non-self-anti-inflammatory analgesic antipyretics, characterized by strong efficacy, small dose, good tolerance. Clinical mainly used for anti-inflammatory, analgesic and anti-rheumatic [1]. However, the drug is easy to produce oral gastrointestinal adverse reactions (’), so I use the principle of ffi preparation of diclofenac pain liniment transdermal preparation, to avoid the first pass of the liver and gastrointestinal adverse reactions, transdermal absorption was significant [ ’). This article