论文部分内容阅读
雷公藤对治疗类风湿性关节炎等自身免疫功能亢进性疾病具有肯定疗效。近年来其抗炎,抗肿瘤,免疫调节,抗生育以及抗人类免疫缺陷(HIV)病毒和治疗阿耳茨海默氏病等作用,已成为目前国内外研究的热点。但雷公藤临床使用过程中易出现多脏器毒性损伤,尤其是肾脏毒性发生频繁且中毒后果严重,致使雷公藤的使用和推广受到了限制。本文借鉴前人使用雷公藤用药规律的经验,深入归类分析,探索和总结中医处方的规律,并依据“异类相制”理论指导下的“扶正制毒”中药配伍方法,提出了雷公藤肾毒性配伍减毒的组方原则,针对雷公藤导致的毒副症状,利用中医中药辨证筛选出合适的药物与之配伍减毒,依法遣药组方,发挥其相辅相成、相反相制的综合作用,以期为提高雷公藤临床应用的安全性提供参考。
Tripterygium for the treatment of rheumatoid arthritis and other autoimmune diseases have a positive effect of hyperthyroidism. In recent years, its anti-inflammatory, anti-tumor, immunomodulatory, anti-fertility and anti-human immunodeficiency virus (HIV) and the treatment of Alzheimer’s disease and other roles, has become the focus of research at home and abroad. However, the clinical use of Tripterygium prone to multiple organ toxicity damage, especially the frequent occurrence of renal toxicity and severe poisoning, resulting in the use and promotion of Tripterygium restrictions. Based on the experience of using the law of using Tripterygium wilfordii in the past, this paper deeply analyzes and explores the rules of TCM prescriptions and puts forward the methods of compatibility of traditional Chinese medicine under the guidance of “heterogeneous phase ” theory The triptolide nephrotoxicity compatibility attenuated the principle of the parties, in view of the toxic side effects caused by Tripterygium, the use of traditional Chinese medicine dialectical screening of appropriate drugs and its compatibility with attenuated, according to the law of the party, to play its complement each other, the opposite phase system In order to provide a reference for improving the safety of Tripterygium clinical application.