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目的：探讨缺血预处理（ＰＣ）对大鼠小肠Ｉ／Ｒ损伤的保护作用及其机理。方法：采用小肠Ｉ／Ｒ模型，分别观察血压、肠道组织损伤和血管床功能改变。结果：ＰＣ减轻了小肠粘膜出血损伤及整体血压下降，组织ＭＤＡ含量和血浆ＬＤＨ活性降低（Ｐ＜０．０ｌ）；肠组织ＥＢ含量和ＭＰＯ活性亦降低（Ｐ＜０．０ｌ）。结论：缺血预处理对小肠Ｉ／Ｒ损伤有保护作用，其机理与血管床受到保护有关。
Objective: To investigate the protective effect of ischemic preconditioning (PC) on small intestine I / R injury in rats and its mechanism. Methods: Small intestine I / R model was used to observe the changes of blood pressure, intestinal tissue injury and vascular bed function. Results: PC reduced intestinal mucosal hemorrhage, decreased whole blood pressure, reduced MDA content and LDH activity in plasma (P <0.01), reduced EB content and MPO activity in intestinal tissue (P <0.01). CONCLUSION: Ischemic preconditioning has a protective effect on I / R injury in small intestine, and its mechanism is related to the protection of vascular beds.