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作者以往的实验显示,肝细胞癌患者红细胞凝集的植物血凝素(EPHA)反应性AFP-P_4(或AFP-P_4+AFP-P_5)以及兵豆凝集素反应性AFP-L_3常增高。在本研究中,作者在低浓度EPHA(0.2g/L)下,延长亲合力电泳,将AFP-P_4和AFP-P_5分别再分为AFP-P_4,-P_4s和AFP-P_5-P_5s。“S”代表慢迁移带,“f”代表快迁移带。另外AFP-P_2和AFP-P_5存在于肝炎和肝硬化患者。在20例肝细胞癌中,17例显示AFP-P_4s,3例显示微量AFP-P_5s,另外AFP-P_4亦增高。在23例胃肠道(20例)和其它(3例)肿瘤中,18例存在AFP-P_5s,6例存在AFP-P_5f。5例卵黄囊肿瘤显示AFP-P_4s和AFP-P_5s主要带,而没有AFP-P_4和AFP-P_5。
The author’s previous experiments showed that erythrocyte agglutination of phytohemagglutinin (EPHA) reactive AFP-P4 (or AFP-P_4+AFP-P_5) and warfarin agglutinin-reactive AFP-L_3 often increased in patients with hepatocellular carcinoma. In this study, the authors extended electrophoresis at a low concentration of EPHA (0.2 g/L) and subdivided AFP-P_4 and AFP-P_5 into AFP-P_4, -P_4s and AFP-P_5-P_5s, respectively. “S” represents the slow migration zone and “f” represents the fast migration zone. In addition, AFP-P_2 and AFP-P_5 are present in patients with hepatitis and cirrhosis. Of the 20 hepatocellular carcinomas, 17 showed AFP-P 4s, 3 showed trace AFP-P 5s, and AFP-P 4 also increased. In 23 cases of gastrointestinal tract (20 cases) and other (3 cases) tumors, 18 cases had AFP-P 5s and 6 cases had AFP-P 5f. Five yolk sac tumors showed AFP-P_4s and AFP-P_5s major bands, but not AFP-P_4 and AFP-P_5.