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在笔者实验室发表于J.Org.Chem.的论文(本文参考文献[12])中提出的芳香胺离子与腺苷反应所得到非常特殊的亚胺加成物的生成机理指出,腺嘌呤对4-联苯胺离子中对位碳原子初始进攻是得到非常特殊的亚胺加成物的最可行生成路径,而腺嘌呤对4-联苯胺离子中邻位碳原子初始进攻的其它3个反应路径,由于涉及几个氢转移过程的反应的能垒较高,所以,理论上讲,它们是不能发生的。但是,研究发现,如果在这些氢转移过程中有水作为媒介,它们的能垒会大大的降低,从而可能使腺嘌呤对4-联苯胺离子中邻位碳原子初始进攻的3个反应路径成为对对位碳原子初始进攻路径的竞争性反应路径。
The mechanism of formation of the very specific imine adducts resulting from the reaction of aromatic amines with adenosine presented in my laboratory paper published in J. Org. Chem. (Ref. [12]) states that the adenine pair The initial attack of the para-carbon atom in the 4-benzidine ion is the most viable route to obtain a very specific imine adduct, and the other three pathways of adenine for the initial attack of the ortho-carbon atom in the 4-benzidine ion , They theoretically can not occur due to the high energy barrier of reactions involving several hydrogen transfer processes. However, the study found that if water is used as a medium in these hydrogen transfer processes, their energy barrier will be greatly reduced, making it possible for the three reaction paths of adenine to initially attack adjacent carbon atoms in 4-benzidine ion to become Competitive response to the initial offensive path of para carbon.