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（目的）探讨顺铂、氟脲嘧啶化疗综合放疗治疗局部晚期鼻咽癌的疗效。（方法）87例病理证实的Ⅲ、Ⅳa期鼻咽癌进行随机分组观察，45例采用综合治疗（治疗组），42例采用单纯放疗（对照组）。两级的照射方法和剂量相同。治疗组化疗：顺铂100mp／m2，第1天静脉注射，氟脲嘧啶750mg／m2，第1～5天静脉注射；于放疗前1周和放疗40Gy时以及放疗结束2～4周后进行。（结果）鼻咽部原发肿瘤消退率：治疗组95．6％，对照组81％（P＜0．05）。颈淋巴结完全消退率：治疗组93％、对照组74％（P＜0．05））。治疗组2、3、4年生存率分别为82．2％、75．5％、66，6％，对照组分别为61．9％、54．8％、47．7％（P＜0．05）。治疗组2、3、4年局控率分别为778％、68．9％、622％，对照组分别为57．2％、476％、40％（P＜0．05）。治疗组出现远处转移的中位时间18.6个月，对照组7．9个月，两组比较差异显著（P＜0．05）。（结论）顺铂、氟脲嘧啶化疗加放疗有助于改善肿瘤的消退率、局部控制率、延长出现远处转移的时间，提高局部晚期鼻咽癌患者的生存率，其毒副反应可以耐受。
(Objective) To investigate the efficacy of cisplatin and 5-fluorouracil chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma. (Methods) Eighty-seven pathologically confirmed stage III and IVa nasopharyngeal carcinomas were randomly divided into groups. 45 cases were treated with comprehensive treatment (treatment group), and 42 cases were treated with simple radiotherapy (control group). The two-stage irradiation method and dose are the same. Treatment group chemotherapy: cisplatin 100mp/m2, intravenous injection on the first day, fluorouracil 750mg/m2, intravenous injection on the first 1-5 days; 1 week before radiotherapy and 40Gy radiotherapy and 2 to 4 weeks after radiotherapy. (Results) The primary tumor regression rate in the nasopharyngeal area was 95.6% in the treatment group and 81% in the control group (P<0.05). The rate of complete resolution of cervical lymph nodes was 93% in the treatment group and 74% in the control group (P<0.05). The survival rates of the treatment group at 2, 3, and 4 years were 82.2%, 75.5%, and 66.6%, respectively, and 61.9%, 54.8%, and 47.7% in the control group (P<0. 05). The control rates in the treatment group were 778%, 68.9%, and 622% in 2, 3, and 4 years, respectively, and 57.2%, 476%, and 40% in the control group (P<0.05). The median time for distant metastasis was 18.6 months in the treatment group and 7.9 months in the control group. There was a significant difference between the two groups (P<0.05). (Conclusion) Cisplatin and 5-fluorouracil chemotherapy and radiotherapy help to improve the tumor regression rate, local control rate, prolong the time of distant metastasis, improve the survival rate of patients with locally advanced nasopharyngeal carcinoma, and their toxicity can be tolerated. Accepted.