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目的:研究神经节苷脂与头部贴敷式亚低温联合治疗新生鼠缺氧缺血性脑损伤时脑组织内一氧化氮(NO)和(MDA)含量的变化,为新生儿缺氧缺血性脑病的治疗提供理论依据。方法:将88只WISTAR新生鼠随机分为四组,神经节苷脂治疗组(IG)、头部贴敷式亚低温治疗组(IH)、联合治疗组(IB)以及对照组(CN)。结果:CN组NO和MDA的含量明显升高,IG、IH以及IB组NO和MDA均明显下降。结论:神经节苷脂和亚低温通过降低NO和MDA的含量保护缺氧缺血神经元,二者联合效果更好。
OBJECTIVE: To study the changes of nitric oxide (NO) and malondialdehyde (MDA) contents in brain tissue of neonatal rats with hypoxic-ischemic brain injury after ganglioside and head-mounted mild hypothermia, Hemorrhagic encephalopathy treatment provides a theoretical basis. Methods: Eighty Wistar newborn rats were randomly divided into four groups: ganglioside treatment group (IG), head-mounted hypothermia treatment group (IH), combined treatment group (IB) and control group (CN). Results: The contents of NO and MDA in CN group were significantly increased, and the levels of NO and MDA in IG, IH and IB group were significantly decreased. CONCLUSION: Gangliosides and mild hypothermia protect hypoxic-ischemic neurons by decreasing the levels of NO and MDA, and their combination is better.