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A series of novel N-anilino-2-substituted-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer cell lines,Bel-7402 and HT-1080.Most of the compounds inhibited the cell proliferation at a low concentration.Seven compounds,VI5,VI7,VI10,and VI12―VI15,possessed marked antiproliferative activity superior to that of cisplatin.Of these seven initial hits,compound VI10 was the most active.
A series of novel N-anilino-2-substituted-5-methyl- [1,2,4] triazolo [1,5-a] pyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer Cell lines, Bel-7402 and HT-1080. Host of the compounds inhibited the cell proliferation at a low concentration. Seventh compounds, VI5, VI7, VI10, and VI12-VI15, possessed marked antiproliferative activity superior to that of cisplatin. seven initial hits, compound VI10 was the most active.