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目的通过对社区获得性多叶性肺炎(MLP)进行系统回顾和Meta分析,以明确MLP与临床预后的相关性。方法检索2002年1月至2014年6月Pub Med中MLP与临床结果之间有关联的英文文献报告。对可能相关的研究报告,由2名研究人员交叉审阅核定。资料汇总后对MLP与病死率、临床结果及疗效不佳之间的的比值比(OR)及随机效应的Meta分析。结果 22项文献研究入选本报告。总共调查了肺炎患者11456例,其中MLP患者2897例(25.3%)。总体数据汇总后全部临床资料进行统计处理和异质性检验,我们仅限于对其中的社区获得性肺炎(CAP)患者进行Meta分析。结果表明,与社区获得性MLP相关的病死率明显上升,OR为2.57(95%CI 1.83~3.61),异质性检验无统计学意义(I2=0)。结论 MLP是增加CAP病死率的独立危险因素,可作为评价CAP预后指数的一个重要指标。
Objective To systematically review and meta-analysis community acquired leaf-lobe pneumonia (MLP) to clarify the correlation between MLP and clinical prognosis. Methods The English literature of the association between MLP and clinical outcome in Pub Med from January 2002 to June 2014 was retrieved. The research report may be relevant, cross-examined by two researchers approved. Data were pooled for meta-analysis of odds ratio (OR) and random effects between MLP and case-fatality rate, clinical outcome, and poor response. Results 22 literature studies were selected for this report. A total of 11456 patients with pneumonia were investigated, of whom 2897 were MLP (25.3%). All clinical data were pooled and heterogeneously tested after pooled population data, and we were limited to Meta-analysis of patients with community-acquired pneumonia (CAP). The results showed that the community-acquired MLP-related mortality increased significantly, OR was 2.57 (95% CI 1.83 ~ 3.61), heterogeneous test was not statistically significant (I2 = 0). Conclusion MLP is an independent risk factor for increasing the mortality of CAP and may be used as an important index to evaluate the prognosis index of CAP.