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目的 探讨乙肝特异性转移因子、肝康灵和左旋咪唑涂布剂联用，对无症状ＨＢＶ 携带者细胞免疫功能的影响。方法用葡萄球菌蛋白Ａ（ＳＰＡ） 花环法制定了治疗Ⅰ组（３８ 例大三阳） 、治疗Ⅱ组（９７ 例小三阳） 、对照Ⅰ组（２８ 例大三阳） 及对照Ⅱ组（５５ 例小三阳）Ｔ 淋巴细胞亚群。结果 治疗Ⅰ组、治疗Ⅱ组经三种药物治疗后ＣＤ４ 百分率均明显增加（Ｐ＜ ０ ．０５） ；ＣＤ８ 百分率均明显下降（ｐ ＜ ０ ．０５） ；ＣＤ４／ＣＤ８ 明显升高（ｐ＜ ０ ．０５） 。而对照Ⅰ组、对照Ⅱ组则治疗前后比较无此等变化（ｐ ＞ ０ ．０５） 。提示 乙肝特异性转移因子等三种药物联用，具有明显的促进ＣＤ４ 细胞成熟分化；抑制ＣＤ８ 细胞；改变ＣＤ４／ＣＤ８ 比值等作用，从而调节细胞免疫功能、减轻肝细胞免疫损伤。
Objective To investigate the effects of Hepatitis B-specific transfer factor, heparin and levamisole on the cellular immune function of asymptomatic HBV carriers. Methods The treatment group Ⅰ (38 cases of big three positive), the treatment group Ⅱ (97 cases of small three positive), the control group Ⅰ (28 cases of big three positive) and the control group Ⅱ (55 cases) were made by the method of Staphylococcus aureus SPA. Cases of three positive) T lymphocyte subsets. Results The percentages of CD4 in treatment group Ⅰ and group Ⅱ after treatment were significantly increased (P <0.05); the percentage of CD8 was significantly decreased (p <0.05); the level of CD4 / CD8 was significantly increased (p <0 .05). The control group Ⅰ, the control group Ⅱ before and after treatment compared with no such change (p> 0.05). Suggesting that hepatitis B-specific transfer factor and other three drugs in combination, has a clear promotion of CD4 cell maturation and differentiation; inhibit CD8 cells; change CD4 / CD8 ratio and so on, thereby regulating cellular immune function, reduce liver cell immune damage.