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半胱氨酰白三烯(LTs)作为一种炎症介质,在变应性鼻炎(AR)及哮喘的发病机制中起着重要的作用,为疾病治疗的靶点。如何认识白三烯在气道炎症发展中的作用?使用白三烯作为激发剂进行鼻激发试验,观察上下气道的反应,能否更好的了解AR和哮喘之间的联系?为白三烯受体拮抗剂(LTRA)的使用提供理论依据?
As an inflammatory mediator, cysteinyl leukotrienes (LTs) play an important role in the pathogenesis of allergic rhinitis (AR) and asthma and are the targets of disease treatment. How to recognize the role of leukotrienes in the development of airway inflammation? Use of leukotrienes as a stimulant for nasal provocation test to observe the upper and lower airway response, can better understand the relationship between AR and asthma? The use of olefin receptor antagonists (LTRA) provide a theoretical basis?