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目的：比较青蒿琥酯和巴利捷克治疗西非塞内加尔恶性疟的疗效。方法：西非恶性疟病儿１９０例，随机分为青蒿琥酯组７６例（男性４７例，女性２９例，年龄６±ｓ３ａ），用青蒿琥酯每次１５ｍｇ／ｋｇ，ｉｖ或１ｍ，于入院后即刻，ｈ４，ｈ２４，ｈ４８给药，２ｄ为一个疗程；巴利捷克组１１４例（男性６８例，女性４６例；年龄６±３ａ），用巴利捷克剂量２５ｍｇ奎宁基质／（ｋｇ·ｄ），ｉｖ或ｉｍ，ｂｉｄ，３ｄ为一个疗程。结果２组血检疟原虫转阴率，退热时间和住院时间各为９４．７％，７８．９％；１．３±０．５ｄ，２．７±１．１ｄ和３．２±１．１ｄ，４．５±１．５ｄ；差别皆有非常显著意义（Ｐ均＜０．０１）。结论：青蒿琥酯疗效优于巴利捷克。
PURPOSE: To compare the efficacy of artesunate and barley in the treatment of falciparum malaria in Senegal, West Africa. Methods: 190 cases of falciparum malaria in West Africa were randomly divided into artesunate group 76 cases (47 males and 29 females, age 6 ± s3a) with artesunate 15mg / kg, iv or 1m, Immediately after admission, h4, h24 and h48 were administered for 2 days. 114 patients (68 males and 46 females; age 6 ± 3a) were enrolled in the Ballycik group. Patients were challenged with basil 25 mg quinine / kg · d), iv or im, bid, 3d for a course of treatment. Results The negative conversion rate, excretion time and length of hospital stay of the two groups were 94.7% and 78.9%, respectively, and were 1.3 ± 0.5d, 2.7 ± 1.1d and 3.2 ± 1 .1d, 4.5 ± 1.5d; the differences are very significant (all P <0.01). Conclusion: Artesunate is superior to Barry Czech.