组胺是存在于细胞中的一种生物胺,它具有很强的生物活性作用。因此有关组胺的研究早就为人们所重视。组胺对效应器靶细胞的直接作用是通过两类组胺受体即H_1和H_2受体而实现的。抗组织胺类药物则是在受体部位上竞争性地拮抗组胺的作用。我们常用的抗组胺类药物均为H_1受体拮抗剂。近年来,通过对组胺的研究合成了一系列的H_2受体拮抗剂,并 Histamine is a biogenic amine present in cells that has a strong biological activity. Therefore, histamine research has long been valued by people. The direct effect of histamine on effector target cells is achieved through two classes of histamine receptors, H 1 and H 2 receptors. Antihistamines are competitive antagonists of histamine at the receptor site. Our commonly used antihistamines are H 1 receptor antagonists. In recent years, through the study of histamine synthesized a series of H 2 receptor antagonists, and