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目的探讨脑梗死急性期的血浆纤维蛋白原水平与预后。方法 200例脑梗死急性期患者,根据患者预后不同分为研究组(发生死亡)和对照组(未发生死亡),各100例。对比两组入院时及起病后3、7 d血浆纤维蛋白原水平。分析血浆纤维蛋白原水平和脑梗死急性期患者死亡的相关性。结果研究组入院时及起病后3、7 d血浆纤维蛋白原水平分别为(1.69±0.49)、(2.84±0.89)、(3.19±1.12)g/L,对照组入院时及起病后3、7 d血浆纤维蛋白原水平分别为(1.23±0.54)、(1.43±0.58)、(1.84±0.76)g/L,研究组均高于对照组,差异均具有统计学意义(t=6.31、13.27、9.97,P<0.05)。血浆纤维蛋白原水平和脑梗死急性期患者死亡具有相关性(r=0.726,P<0.05)。结论脑梗死急性期血浆纤维蛋白原水平高低与患者预后明显相关,高水平血浆纤维蛋白原会增加脑梗死急性期患者死亡率。
Objective To investigate the plasma fibrinogen level and prognosis in acute cerebral infarction. Methods 200 cases of acute cerebral infarction patients, according to the prognosis of patients divided into study group (death occurred) and control group (no death), each 100 cases. The plasma fibrinogen levels were compared between the two groups on admission and on days 3 and 7 after onset. Analyze the correlation between plasma fibrinogen levels and death in patients with acute cerebral infarction. Results The levels of plasma fibrinogen at admission and at 3 and 7 days after onset in the study group were (1.69 ± 0.49), (2.84 ± 0.89) and (3.19 ± 1.12) g / L, respectively (1.23 ± 0.54) and (1.84 ± 0.76) g / L respectively on the 7th day, and the levels of plasma fibrinogen in the study group were significantly higher than those in the control group on the 7th day (t = 6.31, 13.27,9.97, P <0.05). There was a correlation between plasma fibrinogen levels and death in patients with acute cerebral infarction (r = 0.726, P <0.05). Conclusions The level of plasma fibrinogen in acute stage of cerebral infarction is obviously related to the prognosis of patients. High level of plasma fibrinogen will increase the mortality of patients with acute cerebral infarction.