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目的探讨血清标志物胃泌素释放肽前体(pro-GRP)、神经元特异性烯醇化酶(NSE)对小细胞肺癌(SCLC)鉴别诊断的价值。方法选择SCLC患者120例(SCLC组)、非小细胞肺癌(NSCLC)患者130例、良性肺部疾病者80例,以及同期健康体检者90例(健康对照组),检测血清pro-GRP、NSE水平,SPSS13.0进行统计分析,分析各标志物的血清水平和阳性率。Graph-Pad Prism 5进行ROC曲线绘制。结果 SCLC组患者血pro-GRP、NSE水平明显高于NSCLC组、良性肺部疾病组和健康对照组,差异有统计学意义(P<0.05)。SCLC组患者血清pro-GRP阳性率(80.00%)高于其他3组,差异有统计学意义(P<0.05)。SCLC组和NSCLC组NSE阳性率比较差异无统计学意义(P>0.05)。pro-GRP、NSE单独及联合诊断SCLC的ROC曲线下面积分别为0.890、0.810和0.915。结论 NSE只能鉴定良恶性肺部疾病,不能鉴定SCLC和NSCLC;pro-GRP既可鉴定良恶性肺部疾病,还可鉴定肺癌的SCLC和NSCLC病理分型;pro-GRP、NSE联合检测对SCLC的鉴别诊断有重要价值。
Objective To investigate the value of serum markers of pro-GRP and NSE in the differential diagnosis of small cell lung cancer (SCLC). Methods One hundred and seventy patients with SCLC (SCLC group), 130 patients with non-small cell lung cancer (NSCLC), 80 patients with benign lung disease and 90 healthy controls (control group) were enrolled in this study. Serum pro-GRP, NSE Level, SPSS13.0 for statistical analysis, analysis of the serum levels of each marker and the positive rate. Graph-Pad Prism 5 for ROC curve rendering. Results The levels of serum pro-GRP and NSE in SCLC patients were significantly higher than those in NSCLC patients, benign lung disease patients and healthy controls (P <0.05). The positive rate of serum pro-GRP in patients with SCLC (80.00%) was higher than the other three groups (P <0.05). The positive rate of NSE in SCLC group and NSCLC group was no significant difference (P> 0.05). The area under the ROC curve for pro-GRP and NSE alone and in combination with SCLC was 0.890, 0.810 and 0.915, respectively. Conclusions NSE can only identify benign and malignant lung diseases and can not identify SCLC and NSCLC. Pro-GRP can identify benign and malignant lung diseases, as well as pathological classification of SCLC and NSCLC. Pro-GRP and NSE combined detection of SCLC and SCLC The differential diagnosis has important value.