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目的 :探讨健胃口服液抗消化性溃疡的药理作用。方法 :采用水浸应激、幽门结扎、利血平诱发及乙酸损伤等方法造成急慢性胃溃疡模型 ,观察药物对这些模型的影响。结果 :健胃口服液对大白鼠急性应激性溃疡、幽门结扎型溃疡、乙酸损伤型溃疡、小白鼠利血平诱发型溃疡的形成均具有显著的抑制作用 (P <0 .0 5 ,P <0 .0 1) ,能显著减少胃酸及胃蛋白酶的分泌 (P <0 .0 5 )。结论 :健胃口服液具有防治消化性溃疡的作用。
Objective: To investigate the pharmacological effects of Jianwei oral liquid on peptic ulcer. Methods: Acute and chronic gastric ulcer models were induced by flooding stress, pylorus ligation, reserpine-induced and acetic acid injury, and the effects of drugs on these models were observed. Results: Jianwei Oral Liquid had a significant inhibitory effect on acute stress ulcer, pyloric ligation ulcer, acetic acid-induced ulcer and reserpine-induced ulcer in rats (P <0.05, P <0. 01), can significantly reduce the secretion of gastric acid and pepsin (P <0.05). Conclusion: Jianwei Oral Liquid has the effect of preventing and treating peptic ulcer.