肿瘤坏死因子(Tumor Necrosis Factor,TNF)是主要来源于巨噬细胞、能直接杀死肿瘤细胞的物质。TNF的抗癌比活性高,能选择性地使肿瘤发生出血坏死,对正常细胞无影响。它对广范围的肿瘤有细胞毒作用,且无种属特异性,小鼠或家兔的TNF对人癌细胞也有活性,静脉注射给药时作用强而持久,是一种生物效应修饰剂。癌症患者伴发急性细菌感染或注射混合细菌疫苗时,有出现肿瘤缩小的病例。1975 Tumor necrosis factor (TNF) is a substance that is mainly derived from macrophages and directly kills tumor cells. High anti-cancer activity of TNF, can selectively make the tumor hemorrhagic necrosis, no effect on normal cells. It has a wide range of tumor cytotoxicity, and no species-specific, mouse or rabbit TNF is also active on human cancer cells, intravenous injection of strong and long-lasting effect, is a biological effect modifier. Cancer patients with acute bacterial infection or mixed bacterial vaccine injection, there are cases of tumor shrinkage. 1975