目前对于缺血性脑卒中后神经元的保护仍缺乏明确有效的药物治疗。磷酸二酯酶抑制剂可通过增加细胞内cAMP的含量对缺血性神经元发挥保护作用。本文从cAMP对缺血性神经元胞内和胞外的作用,阐述cAMP对缺血神经元发挥保护作用的机制,并试图为磷酸二酯酶抑制剂等cAMP增效药物的临床应用提供理论基础。 At present, the protection of neurons after ischemic stroke still lacks a definite and effective drug treatment. Phosphodiesterase inhibitors can protect ischemic neurons by increasing intracellular cAMP levels. This article from the cAMP on ischemic neuronal intracellular and extracellular effects of cAMP on ischemic neurons protective mechanism of action and try to phosphodiesterase inhibitors such as cAMP synergistic drug clinical application of the theory to provide .