用胸腺切除术治疗重症肌无力已有40多年的历史了,40多年的临床实践经验证明胸腺切除术确实是一种最根本、最有效、最安全、最持久的治疗方法。特别是近些年来各国学者对本疗法作用机理的阐明,手术适应症的扩大,术后疗效的演变,类固醇疗法的联合以及手术方法的改进等作了大量的研究,取得了很大进展,现综述如下。一、作用机理的阐明(一)胸腺切除术可去掉重症肌无力患者发生自体免疫反应的抗原的发源地。Wekerle 实验发现重症肌无力患者胸腺内干细胞由于不正常的刺激而分化成肌 The use of thymectomy for the treatment of myasthenia gravis has been over 40 years old. More than 40 years of clinical experience has proven that thymectomy is indeed the most fundamental, most effective, safest and most durable treatment. Especially in recent years, scholars from various countries have made a lot of studies on the elucidation of the mechanism of action of this therapy, the expansion of surgical indications, the evolution of postoperative efficacy, the combination of steroid therapy, and the improvement of surgical methods, and have made great progress. as follows. First, the mechanism of action elucidation (a) thymectomy can remove the origin of the antigen in patients with myasthenia gravis autoimmune reactions. Wekerle’s Experiment Finds That Thymic Stem Cells in Myasthenia Gravis Divide into Muscles Due to Irregular Stimulation