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目的:探讨加味二至煎对便秘型肠易激综合征(C-IBS)的作用机制。方法:40只Wistar大鼠随机分为5组,分别给予西沙比利、加味二至煎及复方芦荟胶囊灌胃,观察大鼠粪便含水量、小肠墨汁推进率和血浆中的血管活性肠肽、P物质含量的变化。结果:加味二至煎能够增加C-IBS大鼠小肠墨汁推进百分率,升高肠黏膜组织中SP、VIP含量。结论:加味二至煎可通过调整紊乱的胃肠激素的分泌释放而调节C-IBS大鼠的肠运动功能。
Objective: To explore the mechanism of action of modified Erzhi decoction on constipation-predominant irritable bowel syndrome (C-IBS). METHODS: Forty Wistar rats were randomly divided into 5 groups and were given intragastric administration of cisapride, Jiawei Erzhi decoction and compound aloe capsules respectively. The water content of feces, the propulsion rate of intestinal ink, and vasoactive intestinal peptide in plasma were observed. Changes in substance content. Results: Modified Erzhi decoction can increase the percentage of intestinal ink promotion in C-IBS rats and increase the content of SP and VIP in intestinal mucosa. Conclusion: Modified Erzhi decoction can regulate the intestinal motor function of C-IBS rats by adjusting the release of disordered gastrointestinal hormones.