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目的：分析肾小球疾病患者血浆纤维蛋白原（Fibrinogen，FIB）浓度的影响因素，并探讨其临床意义。方法测定246例肾活检肾小球疾病患者血浆FIB浓度。按尿蛋白排泄量（UP）分为肾病范围蛋白尿患者60例，非肾病范围蛋白尿186例，同时检测血清白蛋白（ALB）水平、总胆固醇（TC）、甘油三酯（TG）、UP以及血肌酐值（SCr）等指标，并分析血浆FIB浓度与上述指标之间的相关性。并观察不同病理类型与上述临床指标之间的相关性。结果1.肾病范围蛋白尿组血浆FIB浓度显著高于非肾病范围蛋白尿组，差异具有统计学意义（F=9.226，P＜0.01）。2.肾病范围蛋白尿组血浆FIB浓度与ALB呈负相关关系（r=-0.363，P＜0.05），与TC（r=0.327，P＜0.05）、TG（r=0.285，P＜0.05）及UP（r=0.361， P＜0.05）均呈正相关关系，与SCr无相关性（r=0.003，P＞0.05）。3.非肾病范围蛋白尿组血浆FIB浓度与ALB呈负相关关系（r=-0.464，P＜0.05），与TC（r=0.304，P＜0.05）、TG（r=0.175，P＜0.05）、SCr（r=0.277，P＜0.05）及UP （r=0.302，P＜0.05）均呈正相关关系。4.肾病范围蛋白尿微小病变性肾炎组血浆FIB浓度、UP较其余4组显著升高（P＜0.05），ALB水平较其余4组明显降低（P＜0.05），TC、TG与其余组间比较差异无统计学意义（P＞0.05）。非肾病范围蛋白尿微小病变性肾炎组血浆FIB浓度显著低于其余4组（P＜0.05），TG较其余4组明显降低（P＜0.05）；膜性肾病组UP显著高于系膜增生、微小病变组（P＜0.05），ALB水平明显低于其余各组（P＜0.05）。结论高FIB血症与低白蛋白血症密切相关，与肾脏病理类型无直接关系。“,”Objective To analyze plasma ifbrinogen levels and its inlfuencing factors and to study its clinical signiifcance. Methods Plasma ifbrinogen levels in 246 patients with glomerular disease diagnosed by renal biopsy were measured. 60 patients had nephropathic proteinuria and 186 patients had non-nephropathic proteinuria. The levels of serum albumin (ALB), serum creatinine (SCr), total cholesterol (TC), triglyceride (TG), and proteinuria in 24 hours (UP) were detected, and the correlation between plasma ifbrinogen levels and those indexes were ana-lyzed. The correlation between different types of renal pathology and those indexes were observed. Results 1.The plasma fibrinogen level in the group of nephropathic proteinuria was significantly higher than the other group (F=9.226, P<0.01). 2.The plasma fibrinogen level in the group of nephropathic proteinuria was significantly negative correlated with ALB (r=-0.363, P<0.05), positively correlated with TC (r=0.327, P<0.05), TG (r=0.285, P<0.05), and UP (r=0.361, P0.05). 3.The plasma ifbrino-gen level in the group of non-nephropathic proteinuria was signiifcantly negative correlated with ALB (r=-0.464, P<0.05), positive correlated with TC (r=0.304, P<0.05), TG (r=0.175, P<0.05), SCr (r=0.277, P<0.05), and UP (r=0.302, P<0.05). 4.The levels of plasma ifbrinogen and UP in minimal change nephropathy group of ne-phropathic proteinuria were signiifcantly higher than other groups (P<0.05), ALB was lower than other groups (P0.05). In the group of non-nephropathic protein-uria, the FIB level of minimal change nephropathy group was signiifcantly lower than other groups (P<0.05), TG was lower than the others (P<0.05). The level of UP in membranous nephropathy group was signiifcantly higher than the groups of minimal change nephropathy and mesangial proliferative glomerulonephritis (P<0.05), ALB was lower than others (P<0.05). Conclusion High plasma ifbrinogen is closely correlated with hypo-albuminae-mia, but is not signiifcantly correlated with renal pathological types.