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现将我院1981年～1989年住院确诊的皮质醇增多症所致的骨质疏松23例作一临床分析. 临床资料与结果一般资料 30例,男10例,女20例。年龄15～54岁,平均31.7岁。病程2月～8年。有典型的皮质醇增多症外貌和临床表现。尿17-羟类固醇(17-OH)43.8～122.8μmol/24 h,平均80.2±20.9μmol/24h,>69μmol/24h20例,其中出现代谢性骨病19例,<69μmol/24h10例,其中出现代谢性骨病4例,两者有非常显著性差异(P<0.01).尿17-酮类固醇(17-ks)19.3～90.3μmol/24h,平均48.6±19.3μmol/24h。17例血皮质醇测定均>828nmol/L(8Am),全部出现骨质疏松。血钾3.3～5 mmol/L,血钙2.1～2.75mmol/L,24小时尿钙2～4.65mmol/24h,血尿素氮2.86～
Now in our hospital from 1981 to 1989 confirmed cortisol syndrome caused by osteoporosis in 23 cases for a clinical analysis of clinical data and results of 30 cases of general information, 10 males and 20 females. Aged 15 to 54 years old, average 31.7 years old. Duration of 2 months to 8 years. A typical appearance of cortisol hypersecretion and clinical manifestations. Urine 17-hydroxysteroid (17-OH) 43.8 ~ 122.8μmol / 24 h, an average of 80.2 ± 20.9μmol / 24h,> 69μmol / 24h20 cases, including metabolic bone disease in 19 cases, <69μmol / 24h10 cases, There were 4 cases of osteodystrophy (P <0.01), and the urinary 17-ketosteroids (17-ks) ranged from 19.3 to 90.3μmol / 24h with an average of 48.6 ± 19.3μmol / 24h. 17 cases of blood cortisol were measured> 828nmol / L (8Am), all osteoporosis. Blood potassium 3.3 ~ 5 mmol / L, blood calcium 2.1 ~ 2.75mmol / L, 24 hours urinary calcium 2 ~ 4.65mmol / 24h, blood urea nitrogen 2.86 ~