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目的 :观察硫酸依替米星注射液 (悉能 )的临床有效性及安全性。方法 :采用开放临床试验方法治疗 53例细菌感染性疾病 ,依替米星 10 0mg 次 ,每 12h 1次 ,静脉滴注 ,疗程 5～ 10d,部分病人 11～ 13d,性病病人均为 3d。结果 :临床治愈率为 6 6 .0 4 % ,总有效率为 88.6 8% ,其中呼吸系统感染有效率为 79.31% ,泌尿道感染有效率为 10 0 %。细菌培养阳性率为 79.2 4 % ,治疗后细菌清除率为 78.57% ;不良反应发生率为 3.77%。结论 :硫酸依替米星是毒性较低、安全性好、疗效较强的广谱抗生素。
Objective: To observe the clinical efficacy and safety of etimicin sulfate injection (Xijing). Methods: An open clinical trial was conducted to treat 53 cases of bacterial infectious diseases. Etimicin was administered in a dose of 100 mg twice daily for 12 days. The course of treatment was 5 to 10 days. Some patients were treated for 11 to 13 days. The patients with STD were all 3d. Results: The clinical cure rate was 66.04% and the total effective rate was 88.6%. The effective rate of respiratory system infection was 79.31% and the urinary tract infection rate was 100%. The positive rate of bacterial culture was 79.2 4%. The bacterial clearance rate after treatment was 78.57%. The incidence of adverse reactions was 3.77%. Conclusion: Etimicin sulfate is a less toxic, safe and effective broad-spectrum antibiotics.