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目的探讨一氧化氮 (NO)和肿瘤坏死因子 (TNF)在急性胰腺炎中的作用。方法采用比色法和平衡法分别对急性水肿型胰腺炎 (AEP)患者 30例和急性坏死型胰腺炎 (ANP)患者 2 0例以及正常人对照组 30例外周血进行NO和TNF水平检测。结果AEP和ANP组患者NO和TNF水平显著高于对照组 (P <0 0 5 ) ;ANP组NO和TNF水平显著高于AEP组。结论NO和TNF在急性胰腺炎的发生、发展中起重要作用。
Objective To investigate the role of nitric oxide (NO) and tumor necrosis factor (TNF) in acute pancreatitis. Methods The levels of NO and TNF in 30 patients with acute edematous pancreatitis (AEP) and 20 patients with acute necrotizing pancreatitis (ANP) and 30 normal controls were measured by colorimetry and balance method respectively. Results The levels of NO and TNF in AEP and ANP groups were significantly higher than those in control group (P <0.05). The levels of NO and TNF in ANP group were significantly higher than those in AEP group. Conclusion NO and TNF play an important role in the occurrence and development of acute pancreatitis.