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内源性洋地黄因子（ＥＤＦ）是体内产生和分泌的一种内源性洋地黄样生物活性物质。ＥＤＰ与慢性肝病的关系国内报道尚不多见。本文应用放免法检测６８例慢性肝病患者及３０例健康人的血清ＥＤＦ，旨在探讨ＥＤＦ与慢性肝病的关系。结果表明，慢性肝炎、肝硬化患者血清ＥＤＦ浓度明显高于对照组（Ｐ＜０．０５），其中慢性活动性肝炎组较肝硬化组ＥＤＦ含量为高，但两组无显著性差异（Ｐ＞０．０５）。慢性活动性肝炎患者治疗后血清ＥＤＦ含量明显降低，治疗前后比较有显著性差异。分析慢性肝病患者血清ＥＤＦ水平增高的原因，我们认为可能与下列因素有关：①慢性肝病患者的水潴留；②慢性肝病患者门脉压力增高；③ＥＤＦ在肝脏中代谢。
Endogenous digitalis (EDF) is an endogenous digitalis-like bioactive that is produced and secreted in vivo. The relationship between EDP and chronic liver disease Domestic reports are rare. In this paper, 68 patients with chronic liver disease and 30 healthy people serum EDF was detected by radioimmunoassay to explore the relationship between EDF and chronic liver disease. The results showed that the serum EDF levels in patients with chronic hepatitis and cirrhosis were significantly higher than those in the control group (P <0.05). EDF content in chronic active hepatitis group was higher than that in liver cirrhosis group, but there was no significant difference between the two groups (P> 0.05). Serum EDF levels in patients with chronic active hepatitis were significantly lower after treatment, there was a significant difference before and after treatment. Analysis of patients with chronic liver disease increased serum EDF causes, we think may be related to the following factors: ① chronic liver disease in patients with water retention; ② portal hypertension in patients with chronic liver disease; ③ EDF metabolism in the liver.