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本文应用流式细胞仪和单克隆抗体检测76例宫颈癌患者治疗前、后以及6个月后外周血T细胞亚群的分布。实验结果表明,患者外周血中总T细胞(OKT_3)低于正常对照组(p<0.05),T辅助/诱导细胞亚群(OKT_4)随肿瘤进展而下降,T抑制细胞亚群(OKT_8)明显上升,T_4/T_8值有显著差异(p<0.001)。各期宫颈癌治疗后显示总T细胞下降,T_4亚群变化不大,T_8亚群Ⅰ期下降,Ⅲ期上升明显。T_4/T_8值Ⅰ期正常,Ⅱ期略下降,Ⅲ期比例倒置。临床观察宫颈癌T细胞亚群的动态,能客观地反映宫颈癌患者的免疫状况,为临床提供一定的参数。
In this paper, the distribution of T lymphocyte subsets in peripheral blood of 76 patients with cervical cancer before and after treatment and 6 months after treatment were detected by flow cytometry and monoclonal antibody. The results showed that the total T cell (OKT_3) in peripheral blood of patients was lower than that of the normal control group (p <0.05), the T helper / induced cell subpopulation (OKT_4) decreased with the progress of tumor, and the T suppressor subpopulation (OKT_8) Rise, T_4 / T_8 values were significantly different (p <0.001). After treatment of all stages of cervical cancer, total T cells decreased, T_4 subgroup changed little, T_8 subpopulation decreased in stage Ⅰ, Ⅲ increased significantly. T_4 / T_8 value of the first phase of normal, slightly decreased in stage Ⅱ, stage Ⅲ inverted. Clinical observation of cervical cancer T cell subsets of the dynamic, objectively reflect the immune status of patients with cervical cancer, to provide some clinical parameters.