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目的探讨急性百草枯中毒患者血清C-反应蛋白浓度、外周血白细胞计数与预后的关系。方法急性百草枯中毒患者47例,以住院期间死亡为观察终点,分为存活组和死亡组。两组患者分别于中毒后第1天、第3天及第7天检测血清C-反应蛋白浓度及外周血白细胞计数,两组间比较并进行统计学分析。结果死亡组中毒后第1天、第3天及第7天血清C-反应蛋白浓度明显高于存活组(P<0.01);死亡组中毒后第3天及第7天外周血白细胞计数明显高于存活组(P<0.01)。结论血清C-反应蛋白浓度及外周血白细胞计数是判断急性百草枯中毒病情严重程度及预后的可靠指标,且C-反应蛋白浓度的敏感性更高。
Objective To investigate the relationship between serum C-reactive protein and peripheral blood leukocyte count and prognosis in patients with acute paraquat poisoning. Methods Acute paraquat poisoning in 47 cases of patients, hospitalized during the death as the end point, divided into survival and death groups. The levels of serum C-reactive protein and peripheral leukocyte counts in the two groups were detected on the first day, the third day and the seventh day after poisoning respectively. The two groups were compared and statistically analyzed. Results The concentrations of serum C-reactive protein in the dead group were significantly higher than those in the surviving group (P <0.01) on the 1st day, the 3rd day and the 7th day after poisoning. The peripheral blood leukocyte counts on the 3rd day and the 7th day after death in the death group were significantly higher In the survival group (P <0.01). Conclusions Serum C-reactive protein level and peripheral white blood cell count are reliable indicators to judge the severity and prognosis of acute paraquat poisoning, and C-reactive protein is more sensitive.