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骨折临床愈合是一个相对缓慢的过程,由于全身性因素、生物学因素、骨折局部条件及手术的影响等,部分患者可出现骨折延迟愈合和不愈合。辛伐他汀是一种能够降低血清胆固醇和甘油三酯的有效药物,近年来国内外大量实验证明,辛伐他汀能增加骨密度、促进骨生长、有效预防或减少骨质疏松症。淫羊藿是一种传统的补肾阳、强筋骨、祛风湿的中药,近年研究证明其提取物亦具有促进骨形成作用。本文就此二种药物促进骨折愈合研究有关的文献进行综述,进一步分析二者单独及联合应用促进成骨作用的机制。
Fracture clinical healing is a relatively slow process, due to systemic factors, biological factors, the local conditions of fractures and the impact of surgery, some patients may have delayed fracture healing and nonunion. Simvastatin is an effective drug that can lower serum cholesterol and triglycerides. In recent years, a large number of experiments both at home and abroad have proved that simvastatin can increase bone density, promote bone growth and effectively prevent or reduce osteoporosis. Epimedium is a traditional kidney yang, strong bones, rheumatism traditional Chinese medicine, in recent years, studies have shown that its extract also has the role of promoting bone formation. In this paper, we review the literature about the two drugs to promote fracture healing and further analyze the mechanism of both of them in promoting osteogenesis.