探讨以口服去甲氧柔红霉素为主联合化疗方案治疗难治性和复发性白血病的疗效。方法　对难治性及复发性白血病均采用 IE(去甲氧柔红霉素 ,足叶乙甙 )方案诱导化疗 ,完全缓解后再用其他方案巩固强化。结果　完全缓解率 46.1 5% ,部分缓解率 2 3% ,总缓解率69.1 5%。结论　去甲氧柔红霉素口服吸收良好 ,对难治性及复发性白血病有较好疗效 ,值得推广应用。 To investigate the efficacy of oral combination of daunorubicin and chemotherapy in the treatment of refractory and recurrent leukemia. Methods Both refractory and recurrent leukemias were induced with IE (daunorubicin, etoposide). After complete remission, other regimens were used to reinforce them. Results The complete remission rate was 46.1%, the partial remission rate was 23% and the total remission rate was 69.1%. Conclusion Oral daunorubicin is well absorbed orally and has a good curative effect on refractory and recurrent leukemia. It is worth popularizing and applying.