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目的探讨重型乙型肝炎患者血小板参数变化与病情的关系。方法应用电子阻抗法检测７０例重型乙型肝炎患者和１２９例健康者血浆ＰＬＴ及ＭＰＶ。结果患者组ＰＬＴ减少率为７５７％，与健康对照组比较差别有极显著性意义（Ｐ＜０．０１）。患者ＰＬＴ减少，则ＭＰＶ变大（Ｐ＜００１）；患者ＰＬＴ正常，则其ＭＰＶ与健康对照组的差别无显著性意义（Ｐ＞００５）。病情好转组ＰＬＴ比死亡组ＰＬＴ高（Ｐ＜００５）。结论患者ＰＬＴ的变化与疾病预后有一定关系，ＰＬＴ增加，预后良好。且患者ＰＬＴ减少与乙肝病毒感染体内免疫作用有一定关系。
Objective To investigate the relationship between the changes of platelet parameters and the severity of severe hepatitis B patients. Methods Plasma PLT and MPV in 70 patients with severe hepatitis B and 129 healthy controls were detected by electronic impedance spectroscopy. Results The reduction rate of PLT in patients was 75.7%, which was significantly different from that in healthy controls (P <0.01). Patients with PLT decreased, the MPV larger (P <0 01); patients with normal PLT, the MPV and the healthy control group no significant difference (P> 0 05). PLT of patients with improved condition was higher than PLT of death group (P <005). Conclusions The change of PLT in patients has certain relationship with the prognosis of the disease. The PLT is increased and the prognosis is good. And PLT reduction in patients with hepatitis B virus infection in vivo immune function has a certain relationship.