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目的 探讨急性脑梗塞患者用尿激酶（ＵＫ）脑动脉介入溶栓治疗前后对凝血及纤溶系统的影响。方法 检测４４ 例急性脑梗塞（ 发病６ｈ 内） 患者溶栓前及溶栓治疗后３０ｍｉｎ、８ｈ 、２４ｈ、７２ｈ、７ｄ、１４ｄ、２１ｄ 静脉血中血浆α－颗粒膜糖蛋白（ＧＭＰ－１４０） 、Ｄ－ 二聚体（Ｄ－ Ｄｉｍｅｒ）水平，并进行动态观察。结果 ＵＫ 治疗后，机体凝血及纤溶系统均明显活跃，但纤溶系统增强持续时间长于文献报道的静脉溶栓纤溶系统活跃持续时间。结论 脑动脉介入溶栓治疗急性脑梗塞期间，不论闭塞血管是否立即再通，均应在２～３ 周内给予抗凝、降纤等后续治疗
Objective To investigate the effect of urokinase (UK) on the coagulation and fibrinolytic system in patients with acute cerebral infarction before and after cerebral arterial thrombolysis. Methods The plasma level of α-granule membrane glycoprotein (GMP-140) in 44 patients with acute cerebral infarction (within 6 hours of onset) before thrombolysis and at 30 minutes, 8 hours, 24 hours, 72 hours, 7 days, D-dimer (D-dimer) levels, and dynamic observation. Results After the treatment with UK, the coagulation and fibrinolytic system of the body were obviously active. However, the prolongation of the fibrinolytic system was longer than the active duration of fibrinolytic system in the literature. Conclusion Cerebral arterial thrombolysis in the treatment of acute cerebral infarction, irrespective of whether the occlusion of blood vessels immediately re-pass, should be given within 2 to 3 weeks of anticoagulant, fibrinolytic and other follow-up treatment