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作者采用一种新的给药方法——植入微型输注器(装入药液后植入皮下,药物缓慢释放,长时间发挥作用,药液释放量为0.17 ml)进行致畸试验的研究。首先证明微型输注器的植入过程及其在妊娠小鼠皮下长时间输注盐水对胎仔发育无影响,再用植入输注器的给药方法进行吗啡致畸试验,并与作者多次用吗啡皮下给药法进行致畸试验的结果作比较。第1组不给药;第2～5组分别于妊娠第7、8、9、10天皮下注射盐水,为对照组;其余各组于妊娠第7、8、9、10天植入输注器开始
The authors used a new method of administration - implanting a microinjector (subcutaneously subcutaneously into the drug solution, slow release of the drug, long-term use, drug release of 0.17 ml) for teratogenicity studies . First of all, to prove that the microinjector implantation process and its prolonged subcutaneous infusion of saline in pregnant mice had no effect on fetal development, and then transplanted into the infusion method of morphine teratogenicity test, and with the author several times Morphine subcutaneous administration of teratogenicity test results for comparison. Group 1 was not administered; Group 2 ~ 5 were injected subcutaneously on the 7th, 8th, 9th and 10th day of gestation respectively for the control group; the other groups were implanted in the 7th, 8th, 9th and 10th day of gestation Start